American journal of obstetrics and gynecology
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Am. J. Obstet. Gynecol. · Oct 2007
Multicenter StudyAssociations between 2 polymorphisms in the methylenetetrahydrofolate reductase gene and placental abruption.
Heritable thrombophilias have been implicated as a potential cause of abruption by vascular disruption at the uteroplacental interface. Polymorphisms of the methylenetetrahydrofolate reductase (MTHFR) gene have been linked to vascular complications outside of pregnancy, which includes stroke. Given the underlying thrombotic nature of abruption, we hypothesized that polymorphisms in the MTHFR gene are associated with abruption. ⋯ In this population, neither heterozygosity nor homozygosity for the 677C-->T and 1298A-->C variants in MTHFR was associated with placental abruption.