American journal of obstetrics and gynecology
-
Am. J. Obstet. Gynecol. · Mar 2013
ReviewPostpartum hemorrhage in the developed world: whither misoprostol?
We reviewed the literature to determine the optimal medical treatment of postpartum hemorrhage caused by uterine atony. Of the available uterotonics, only misoprostol and oxytocin have undergone rigorous comparative study. ⋯ We conclude that in settings in which oxytocin is available, oxytocin should remain the mainstay of both prophylaxis and first-line treatment of postpartum hemorrhage caused by uterine atony. In the developed world, the use of misoprostol for postpartum hemorrhage should be infrequent.