American journal of obstetrics and gynecology
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Am. J. Obstet. Gynecol. · Jul 2013
Review Meta AnalysisMisoprostol to reduce intraoperative and postoperative hemorrhage during cesarean delivery: a systematic review and metaanalysis.
To evaluate the efficacy and safety of prophylactic misoprostol use at cesarean delivery for reducing intraoperative and postoperative hemorrhage. ⋯ Misoprostol combined with oxytocin appears to be more effective than oxytocin alone in reducing intraoperative and postoperative hemorrhage during cesarean section. There were no significant differences in intraoperative and postoperative hemorrhage when misoprostol was compared to oxytocin. However, these findings were based on a few trials with methodological limitations.
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Am. J. Obstet. Gynecol. · Jul 2013
Comparative StudyGlial fibrillary acidic protein as a biomarker for periventricular white matter injury.
Periventricular white matter injury (PWMI), a precursor of cerebral palsy, traditionally is not diagnosed until 6 weeks of life by head ultrasound scanning. We sought to determine whether early neonatal glial fibrillary acidic protein (GFAP) levels could identify PWMI in low birthweight (<2500 g) infants. ⋯ The ability to predict PWMI with a blood test for GFAP shortly after birth opens the possibility for rapid identification of infants for early intervention and provides a benchmark for the qualification of new therapies to improve neurodevelopmental outcomes.
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Am. J. Obstet. Gynecol. · Jul 2013
Randomized Controlled TrialRisk factors for uterine atony/postpartum hemorrhage requiring treatment after vaginal delivery.
We sought to identify risk factors for uterine atony or hemorrhage. ⋯ Independent risk factors for uterine atony requiring treatment include Hispanic and non-Hispanic white ethnicity, preeclampsia, and chorioamnionitis.