American journal of obstetrics and gynecology
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Am. J. Obstet. Gynecol. · Oct 2018
Meta AnalysisProgestogens in singleton gestations with preterm prelabor rupture of membranes: a systematic review and metaanalysis of randomized controlled trials.
Preterm prelabor rupture of membranes occurs in 3% of all pregnancies. Neonatal benefit is seen in uninfected women who do not deliver immediately after preterm prelabor rupture of membranes. The purpose of this study was to evaluate whether the administration of progestogens in singleton pregnancies prolongs pregnancy after preterm prelabor rupture of membranes. ⋯ Progestogen administration does not prolong pregnancy in singleton gestations with preterm prelabor rupture of membranes.