The American journal on addictions
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Randomized Controlled Trial
Effects of varenicline, nicotine or placebo on depressive symptoms in postmenopausal smokers.
Varenicline carries a black box warning for neuropsychiatric adverse events. ⋯ Pharmacologic aids did not increase depression symptoms in this select population of postmenopausal women without current depression. Smoking cessation does increase depressive symptoms in those with LH-MDD, though the degree of increase was not clinically meaningful.