Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie
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Exp. Toxicol. Pathol. · Mar 2010
A summary of toxicological and chemical data relevant to the evaluation of cast sheet tobacco.
A tiered testing strategy based on a comparative chemical and biological testing program has been developed to evaluate the potential of tobacco processes, ingredients, or other technological developments to change the biological activity that results from burning tobacco. Cast sheet tobacco is a specific type of reconstituted tobacco sheet that can be used in the manufacture of cigarettes. ⋯ Certain statistically significant differences were observed in the chemical and biological studies when the Reference cigarette was compared to each of the Test cigarettes. However, when viewed collectively, the chemical and biological studies demonstrated that inclusion of cast sheet up to 15% in the final blend did not increase the inherent biological activity of mainstream cigarette smoke or CSC.