American journal of critical care : an official publication, American Association of Critical-Care Nurses
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Randomized Controlled Trial
Daily interruption of sedation in patients receiving mechanical ventilation.
Daily interruption of continuous infusion of sedatives has improved outcomes in patients receiving mechanical ventilation in open-label studies. ⋯ The double-blinded design for assessment of sedation interruption in patients receiving mechanical ventilation was safe and effective. Slow recruitment of patients and frequent noncompliance with the protocol suggest that modifications to the protocol are needed.