The American journal of the medical sciences
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Review Meta Analysis
The role of TNF-α 308G>A polymorphism in the risk for ischemic stroke.
Stroke is a common health problem; however, its pathogenesis is not clear. Several studies have examined the association of -308G>A promoter polymorphism in the tumor necrosis factor-α gene (TNF-α) with ischemic stroke susceptibility. However, the results of these studies are inconsistent and the sample sizes of most of the studies were small. Thus, a meta-analysis was conducted to provide a more robust estimate of the effect of the TNF-α 308G>A polymorphism on the risk for ischemic stroke. ⋯ This study suggests that TNF-α 308G>A polymorphism is associated with the risk for juvenile ischemic stroke, whereas it is a protective factor for ischemic stroke in Asians and the adult population. However, in the overall analysis and in Caucasians, a significant association was not found.