The American journal of the medical sciences
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Proton pump inhibitors (PPI) are widely used and implicated in the progression of chronic kidney disease (CKD). We evaluated the relation between chronic PPI use in veterans with CKD G3a to G4 and the rate of decline in renal function. ⋯ The data suggest that chronic PPI use accelerates progression of kidney disease and is associated with increased mortality in CKD patients.
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Fluid therapy is indispensable in treating patients with hemorrhagic shock. However, fluid overload correlates with kidney injury in patients with hemorrhagic shock. We hypothesized that hemodilution after fluid treatment contributes to the kidney injury. ⋯ The hemodilution post hemorrhagic shock and fluid resuscitation led to kidney injury.
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Reduced muscular strength, measured by handgrip strength, has been associated with increased risk for cardiovascular disease (CVD) and mortality. However, the prognostic significance of handgrip strength has been less well-studied in the middle-aged Korean population. This study determined whether handgrip strength predicted 10-year CVD risk in this population and whether there is a sex-specific difference. ⋯ Handgrip strength is a simple and effective screening tool for risk stratification for CVD in middle-aged Korean women.