European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society
-
Observational Study
Failure of an expandable lumbar interbody spacer - a critical analysis of secondary collapse, pseudoarthrosis and revision rates after thoracolumbar fusion.
To report on the failure rates of an expandable interbody spacer, used for spinal instrumented transforaminal lumbar interbody fusion (TLIF) or posterior thoracolumbar interbody fusion (PLIF). ⋯ We provide a critical analysis of our series of patients with use of a specific type of expandable interbody spacer. We noticed failure and secondary collapse in an unacceptably high number of implants, some of which required revision surgery.
-
In the present study, we aimed to analyze whether the Charlson Comorbidity Index (CCI) score was predictive for pseudoarthrosis in patients who underwent with short-segment lumbar decompression and fusion for degenerative lumbar spine disorders (DSD). ⋯ A combined effect of comorbidities might yield higher pseudoarthrosis rates following short-segment decompression and fusion for DSD. Each one-point increment in CCI score and SFI score yielded a 26% increment and a 73% decrement in risk for pseudoarthrosis in those subjects. A cut-off value of 2.5 points for the CCI score could distinguish the subjects who might have pseudoarthrosis following short-segment surgery for DSD.
-
Numerous studies have reported that corrective surgery improves postoperative health-related quality of life (HRQOL) in patients with adult spinal deformity (ASD), and postoperative HRQOL is maintained over 5-year follow-up. However, few studies have investigated factors associated with mid-term patient satisfaction. This study aimed to examine the factors contributing to 5-year patient satisfaction in patients with ASD following corrective surgery. ⋯ These findings underscore the significance of functional and social function improvements following corrective surgery, as they contribute to higher levels of satisfaction among patients with ASD.
-
The endocannabinoid system (ECS) has been well-established to play a crucial role in the regulation of several physiological processes as well as many inflammatory disease conditions. However, its role in intervertebral disc degeneration has been least explored. We aim to investigate the immunomodulatory role of endocannabinoids in regulating IVD health. ⋯ Diagnostic: individual cross-sectional studies with consistently applied reference standard and blinding.
-
Observational Study
Causal effects of plasma proteome on intervertebral disc degeneration: a comprehensive mendelian randomization study.
Intervertebral disc degeneration (IVDD) considerably impacts global disability and quality of life. Although potential links between plasma proteins and IVDD exist, their causal correlation remains undefined. This study explored the causal links between plasma proteins and IVDD employing genome-wide association study data. ⋯ The study underscores the causal correlation between plasma protein levels and IVDD risk. These identified proteins could emerge as unique biomarkers for IVDD, contributing to its predictive measures. The findings further our understanding of IVDD pathomechanisms and prospective therapeutic targets.