Addiction
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Letter Randomized Controlled Trial Clinical Trial
Driving capacity of patients treated with methadone and slow-release oral morphine.
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Randomized Controlled Trial Clinical Trial
Four-year follow-up of imprisoned male heroin users and methadone treatment: mortality, re-incarceration and hepatitis C infection.
To examine the long-term impact of methadone maintenance treatment (MMT) on mortality, re-incarceration and hepatitis C seroconversion in imprisoned male heroin users. ⋯ Retention in MMT was associated with reduced mortality, re-incarceration rates and hepatitis C infection. Prison-based MMT programmes are integral to the continuity of treatment needed to ensure optimal outcomes for individual and public health.
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Randomized Controlled Trial Clinical Trial
Evaluation of an injection depot formulation of buprenorphine: placebo comparison.
Buprenorphine is a mu-opioid partial agonist that is marketed in a sublingual formulation as a treatment for opioid dependence. A microcapsule depot sustained-release formulation has been developed which may offer effective treatment of opioid dependence while also minimizing risks of illicit diversion or patient non-compliance. The present study examined the efficacy of depot buprenorphine in suppressing the opioid withdrawal syndrome and in attenuating the effects of exogenous opioid challenge. ⋯ Results from this double-blind, placebo-controlled study indicate that depot buprenorphine is effective in providing both withdrawal suppression and opioid blockade. Future studies examining additional doses and repeated dosing regimens with depot buprenorphine are warranted.
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Randomized Controlled Trial Clinical Trial
Randomized controlled trial of brief cognitive-behavioural interventions for insomnia in recovering alcoholics.
To test the efficacy of a cognitive-behavioural approach to treating disturbed sleep in abstinent alcoholics. ⋯ Recovering alcoholics with insomnia can achieve better sleep by applying cognitive-behavioural strategies.
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Randomized Controlled Trial Clinical Trial
Randomized controlled trial of brief cognitive-behavioural interventions among regular users of amphetamine.
To identify whether brief cognitive-behavioural interventions are feasible among regular users of amphetamine, to assess the effectiveness of intervention overall and to pilot two- and four-session interventions. ⋯ Brief cognitive-behavioural interventions appear feasible among regular users of amphetamine. A larger randomised controlled trial of the effectiveness of such interventions appears warranted.