Osteoarthritis and cartilage
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Osteoarthr. Cartil. · Nov 2006
Randomized Controlled Trial Multicenter StudyAn analgesic model for assessment of acute pain response in osteoarthritis of the knee.
Osteoarthritis (OA) is frequently treated only during periods of flare, in which rapid onset of analgesia is the outcome target. ⋯ This acute pain model of knee OA flare detected significant pain relief with agents known to relieve pain in OA and placebo within hours after the first treatment dose, allowing assessment of pain relief within hours rather than days or weeks when evaluating analgesic efficacy in OA. This model is undergoing further study to determine optimal walk times, distances, and rates to maximize its sensitivity.