Osteoarthritis and cartilage
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Osteoarthr. Cartil. · Sep 2008
Randomized Controlled TrialEffect of an exercise and dietary intervention on serum biomarkers in overweight and obese adults with osteoarthritis of the knee.
To determine the effects of exercise and weight loss interventions on serum levels of four biomarkers and to examine if changes in biomarker levels correlate with clinical outcome measures in obese and overweight adults with knee osteoarthritis (OA). ⋯ Overall, the E and D interventions did not show a consistent effect on levels of potential OA biomarkers. The four biomarkers showed differences in correlations with outcome measures suggesting that they may measure different aspects of disease activity in OA. The strongest correlations were between serum HA and radiographic measures of OA at baseline.