Osteoarthritis and cartilage
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Osteoarthr. Cartil. · Jan 2017
The knee adduction moment and knee osteoarthritis symptoms: relationships according to radiographic disease severity.
To investigate relationships between external knee adduction moment parameters (KAM) and osteoarthritis (OA) symptoms according to disease severity. ⋯ Relationships between KAM-related parameters and symptoms differ according to underlying radiographic OA severity.
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Osteoarthr. Cartil. · Dec 2016
Cross-cultural validation of the ICOAP and physical function short forms of the HOOS and KOOS in a multi-country study of patients with hip and knee osteoarthritis.
To evaluate the internal consistency and construct validity of the Physical Function short-forms for the Hip and Knee Injury Osteoarthritis Outcome Scores (HOOS-PS/KOOS-PS) and the Intermittent and Constant Osteoarthritis Pain (ICOAP) in a nine country study of patients consulting for total hip or knee replacement (THR or TKR). ⋯ The psychometric properties of the HOOS-PS/KOOS-PS, and ICOAP were maintained across all countries.
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Osteoarthr. Cartil. · Nov 2016
Comparison of the extent to which total hip and total knee arthroplasty restore patient-reported physical function.
To evaluate the extent to which elective total hip arthroplasty (THA) and total knee arthroplasty (TKA) for osteoarthritis (OA) restore normal patient-reported physical function in men and women. ⋯ In women, THA results in greater improvement in WOMAC-PF at approximately 1-year follow-up and better approximates physical function of community-dwelling older adults without OA than TKA does. In contrast, in men, a lack of between-group post-operative WOMAC-PF differences suggests that procedures result in a similar degree of improvement.
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Osteoarthr. Cartil. · Nov 2016
Relationship between structural pathology and pain behaviour in a model of osteoarthritis (OA).
To address the hypothesis that different types of established osteoarthritis (OA) pain behaviours have associations with different aspects of articular pathology, we investigated the relationship between structural knee joint pathology and pain behaviour following injection of a low vs a high dose of monosodium iodoacetate (MIA) in the rat. ⋯ Both pain behaviours were associated with OA structural severity and synovitis. Differences in pain phenotype following low vs higher dose of MIA were identified despite similar structural pathology. OA structural pathology as traditionally measured only partially explains the MIA-induced pain phenotype.