Osteoarthritis and cartilage
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Osteoarthr. Cartil. · Apr 2015
Review Meta AnalysisCurrent evidence on risk factors for knee osteoarthritis in older adults: a systematic review and meta-analysis.
Osteoarthritis (OA) is a leading cause of pain and disability and leads to a reduced quality of life. The aim was to determine the current evidence on risk factors for onset of knee pain/OA in those aged 50 and over. A systematic review and meta-analysis was conducted of cohort studies for risk factors for the onset of knee pain. ⋯ Clinicians can use the identified risk factors to identify and manage patients at risk of developing or increasing knee pain. Obesity in particular needs to be a major target for prevention of development of knee pain. More research is needed into a number of potential risk factors.
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Osteoarthr. Cartil. · Feb 2015
Review Meta AnalysisElectrical stimulation for pain relief in knee osteoarthritis: systematic review and network meta-analysis.
To investigate the efficacy of different electrical stimulation (ES) therapies in pain relief of patients with knee osteoarthritis (OA). ⋯ LevelⅡ, systematic review and network meta-analysis of RCTs.
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Osteoarthr. Cartil. · Nov 2014
Review Meta AnalysisEfficacy of rehabilitation programs for improving muscle strength in people with hip or knee osteoarthritis: a systematic review with meta-analysis.
To analyse the effect of exercise-based rehabilitation programs for improving lower limb muscle strength in individuals with hip or knee osteoarthritis (OA). A systematic search utilizing seven databases identified randomized controlled trials (RCTs) evaluating lower limb strength outcomes of exercise-based interventions for participants with hip or knee OA. All studies were screened for eligibility and methodological quality. ⋯ Only one study reported on a population with hip OA. When compared to a control group, high-intensity resistance exercise demonstrated moderate quality of evidence for large and sustained improvements for knee muscle strength in knee OA patients. Further work is needed to compare different modes of exercise at a LT follow-up for knee OA patients and to address the dearth of literature evaluating exercise interventions in people with hip OA.
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Osteoarthr. Cartil. · Sep 2014
Review Meta AnalysisDesign, study quality and evidence of analgesic efficacy in studies of drugs in models of OA pain: a systematic review and a meta-analysis.
Studies using animal models are important in drug development, but often poorly predict treatment results in man. We investigated factors that may impact on the magnitude of the analgesic treatment effect in animal models of osteoarthritis (OA) pain. ⋯ Attention to study-level moderators and publication bias may improve the ability of research using animal models to predict whether analgesic agents will reduce arthritis pain in man.
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Osteoarthr. Cartil. · Nov 2013
Review Meta AnalysisWhat proportion of people with hip and knee osteoarthritis meet physical activity guidelines? A systematic review and meta-analysis.
To determine the proportion of people with hip and knee osteoarthritis that meet physical activity guidelines recommended for adults and older adults. ⋯ A small to moderate proportion of people with knee and hip osteoarthritis met physical activity guidelines and recommended daily steps. Future research should establish the effects of increasing physical activity in this population to meet the current physical activity guidelines.