Osteoarthritis and cartilage
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Osteoarthr. Cartil. · Sep 2013
Multicenter Study Observational StudyThe relationship between quadriceps muscle weakness and worsening of knee pain in the MOST cohort: a 5-year longitudinal study.
To determine whether quadriceps weakness is associated with elevated risk of worsening knee pain over 5 years. ⋯ Quadriceps weakness was associated with an increased risk of worsening of knee pain over 5 years in women, but not in men.
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Osteoarthr. Cartil. · Sep 2013
Multicenter StudyAcute postoperative pain following hospital discharge after total knee arthroplasty.
The increasingly shorter hospitalization following total knee arthroplasty (TKA) requires patients to assume earlier responsibility to self-manage their pain. Poorly managed acute pain increases the risk of persistent pain, reduces quality of life and increases unnecessary healthcare utilization. This study aims to examine post-discharge pain intensity, pain management behaviors and potential barriers to optimal self-management of pain. ⋯ Effective pain relief after hospital discharge following TKA is a challenge. Many participants reported significant pain, sought further medical help for pain relief and had inadequate information at discharge to effectively self-manage their postoperative knee pain.
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Osteoarthr. Cartil. · Sep 2013
Clinical TrialNeuropathic pain symptoms on the modified painDETECT correlate with signs of central sensitization in knee osteoarthritis.
Clinical tools are needed to identify and target a neuropathic-like phenotype, which may be associated with central sensitization (CS), in osteoarthritis (OA). The modified painDETECT questionnaire (mPD-Q) has face and content validity for identifying neuropathic-like symptoms in knee OA. To further validate the mPD-Q, this study assessed the unknown relationship between mPD-Q scores and signs of CS on quantitative sensory testing (QST) in knee OA. ⋯ Among painful OA knees, higher mPD-Q scores were associated with greater odds of having signs of CS. Thus, the mPD-Q may aid the identification of CS in people with chronic knee OA.
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Osteoarthr. Cartil. · Sep 2013
Experimental pain sensitivity differs as a function of clinical pain severity in symptomatic knee osteoarthritis.
Pain in knee osteoarthritis (OA) has historically been attributed to peripheral pathophysiology; however, the poor correspondence between objective measures of disease severity and clinical symptoms suggests that non-local factors, such as altered central processing of painful stimuli, also contribute to clinical pain in knee OA. Consistent with this notion, recent evidence demonstrates that patients with knee OA exhibit increased sensitivity to painful stimuli at body sites unaffected by clinical pain. ⋯ These findings suggest that altered central processing of pain is particularly characteristic of individuals with moderate to severe symptomatic knee OA.
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Osteoarthr. Cartil. · Sep 2013
Cross-sectional and longitudinal associations between radiographic features and measures of pain and physical function in hand osteoarthritis.
Previous longitudinal studies have shown no associations between increasing amount of radiographic hand osteoarthritis (OA) and levels of hand pain/disability. In this longitudinal study, we aimed to study whether radiographic hand OA was related to pain/disability in cross-sectional and longitudinal settings focusing on joint-specific analyses. ⋯ Radiographic hand OA is associated with tenderness in the same joint, and erosive development strongly predicts future joint tenderness independent of other radiographic features.