Anaesthesia
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Randomized Controlled Trial Clinical Trial
Recovery of mivacurium block with or without anticholinesterases following administration by continuous infusion.
Thirty patients received a bolus dose of 0.2 mg.kg-1 of mivacurium followed by an infusion during anaesthesia with thiopentone, fentanyl and halothane. Neuromuscular block was monitored using train-of-four stimulation and mechanomyography and the block maintained to keep the first response in the train-of-four (T1) at 10% of control. At the end of surgery the patients were randomly allocated to reversal with neostigmine or edrophonium or to spontaneous recovery. ⋯ The times taken for T1 to reach 25, 75 and 90% of control and for the train-of-four ratio to reach 0.7 were significantly shorter (p < 0.05 to 0.001) with neostigmine and edrophonium compared to the spontaneously recovering group. The average (SD) times for attaining the train-of-four ratio of 0.7 were 7.0 (1.2), 6.8 (1.4) and 13.5 (2.3) min respectively for neostigmine, edrophonium and spontaneously recovering groups. There were no differences between endrophonium and neostigmine in any of the recovery times.
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A multilumen catheter guide (jet stylet) with an adapter has been used for various manoeuvres in the upper airway. With the split length, procedures such as change of tracheal tube from oral to nasal nasal to oral position, are possible while the patient's lungs are ventilated by means of high frequency jet ventilation. During high frequency jet ventilation for longer periods of time, for example for microlaryngeal surgery, the central channel of the catheter is used as a conduit for jet delivery, whilst the other channels are used for continuous monitoring of airway pressure and concentration of carbon dioxide in the upper airway.