Anaesthesia
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Comment Letter Historical Article
Prototype Macintosh laryngoscopes and the 'Real McCoy'.
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Randomized Controlled Trial Comparative Study Clinical Trial
Haemodynamic and plasma catecholamine responses during total intravenous anaesthesia for laryngomicroscopy. Thiopentone compared with propofol.
We compared the haemodynamic responses to endolaryngeal procedures during anaesthesia with propofol or thiopentone. Two minutes after administration of glycopyrronium 4 micrograms.kg-1 and alfentanil 17.5 micrograms.kg-1 anaesthesia was induced with either propofol 2.0 mg.kg-1 (n = 8) or thiopentone 5.0 mg.kg-1.min-1, respectively. Muscle relaxation was induced and maintained with suxamethonium. ⋯ With propofol, plasma adrenaline concentrations decreased significantly after induction and remained below baseline values throughout the procedure. After insertion of the operating laryngoscope the haemodynamic response was more pronounced with thiopentone than with propofol. Propofol blocks the catecholamine and haemodynamic responses to endolaryngeal procedures more effectively than thiopentone.