Anaesthesia
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Glycopyrronium 10 micrograms/kg has been compared with atropine 20 micrograms/kg in a mixture with neostigmine 50 micrograms/kg administered for antagonism of residual nondepolarising neuromuscular block in patients over 65 years of age. The initial peak increase in heart rate was less after glycopyrronium, but there were no differences beyond the first two minutes. ⋯ The control of secretions was superior with glycopyrronium. It is suggested that the dosage of anticholinergic agents given with neostigmine could be reduced in elderly patients in comparison to that in younger patients.
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Comparative Study
The neuromuscular transmission monitor. A clinical assessment and comparison with a force transducer.
The neuromuscular transmission monitor (NTM) is a new device for measuring neuromuscular transmission during anaesthesia. We have assessed its use in comparison with a force transducer and found for single twitch and train-of-four modes that there was a strong positive correlation between the two methods. This device appears reliable in use and provides a satisfactory alternative to conventional neuromuscular monitoring.