Der Anaesthesist
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Randomized Controlled Trial Multicenter Study Comparative Study Clinical Trial
[A factorial trial of six interventions for the prevention of postoperative nausea and vomiting].
Untreated, one third of patients who undergo surgery will have postoperative nausea and vomiting. Although many trials have been conducted, the relative benefits of prophylactic antiemetic interventions given alone or in combination remain unknown. ⋯ Because antiemetic interventions are similarly effective and act independently, the safest or least expensive should be used first. Prophylaxis is rarely warranted in low-risk patients, moderate-risk patients may benefit from a single intervention, and multiple interventions should be reserved for high-risk patients.