Human brain mapping
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Human brain mapping · Mar 2016
Randomized Controlled TrialThe effects of low-dose ketamine on the prefrontal cortex and amygdala in treatment-resistant depression: A randomized controlled study.
Low-dose ketamine has been found to have robust and rapid antidepressant effects. A hypoactive prefrontal cortex (PFC) and a hyperactive amygdala have been suggested to be associated with treatment-resistant depression (TRD). However, it is unclear whether the rapid antidepressant mechanisms of ketamine on TRD involve changes in glutamatergic neurotransmission in the PFC and the amygdala. ⋯ Ketamine's rapid antidepressant effects involved the facilitation of glutamatergic neurotransmission in the PFC.