Shock : molecular, cellular, and systemic pathobiological aspects and therapeutic approaches : the official journal the Shock Society, the European Shock Society, the Brazilian Shock Society, the International Federation of Shock Societies
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Altered mitochondrial function by excessive production of reactive oxygen species (ROS) has been considered an important factor in pathogenesis of organ failure in sepsis. ⋯ This CLP study shows that even refined, target-tailored antioxidant treatment is detrimental rather than beneficial. It is suggestive that in young female mice suffering from acute hyperinflammatory CLP sepsis, the negative role of mitochondrial ROS as the contributory factor to MODS is overestimated.
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Intra-abdominal sepsis is a common disease in India. Majority of the patients develop intra-abdominal infections due to secondary bacterial peritonitis. The spectrum of intra-abdominal infections in India is different from that in the West. ⋯ The spectrum of complicated intra-abdominal sepsis in India is considerably different from the west. The high mortality in our setting compared to west is probably due to late patient presentation, lack of ICU facilities and very high incidence of resistant bacteria, as compared to western literature.
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Persistent lymphopenia several days after admission is associated with increased mortality in septic and severely injured patients. We hypothesised that severe abnormalities of the lymphocyte count in the early stages of critical illness are associated with poor outcome in emergency general surgical (EGS) patients. ⋯ : Early profound lymphopenia is a marker of illness severity in critically unwell EGS patients and is associated with increased mortality. Further investigation of early lymphocyte dysfunction in critically ill patients may lead to novel therapeutic interventions.
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Palmitoylethanolamide (PEA), an endogenous fatty acid amide belonging to the family of the N- acylethanolamines (NAEs) and some of its analogues, have shown great efficacy in the treatment of pain and inflammation. Adelmidrol is one of these analogues. The aim of this study was to investigate the effect of Adelmidrol on the modulation of the inflammatory response in a mouse model of collagen-induced arthritis (CIA). ⋯ We demonstrated that Adelmidrol exerts an antiinflammatory effect during chronic inflammation.
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Severe tissue trauma leads to an early excessive activation of the complement and the coagulation system which is associated with a poor outcome. Besides extensive interactions between the two cascades on a fluid-phase level, studies suggest that key molecules in coagulation are expressed on leukocytes. Therefore, we examined the potential crosstalk between complement and coagulation on the leukocyte surface, and aimed to identify the involved molecular mechanisms especially after polytrauma. ⋯ The data are indicative of so far unknown interactions between complement and coagulation on a cellular level and the potential role of leukocyte surface molecules in the development of coagulopathy after trauma.