American journal of respiratory and critical care medicine
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Am. J. Respir. Crit. Care Med. · Oct 2005
Randomized Controlled Trial Clinical TrialTitrating steroids on exhaled nitric oxide in children with asthma: a randomized controlled trial.
Corticosteroids are the antiinflammatory treatment of choice in asthma. Treatment guidelines are mainly symptom-driven but symptoms are not closely related to airway inflammation. The fraction of nitric oxide in exhaled air (FENO) is a marker of airway inflammation in asthma. ⋯ In children with asthma, 1 year of steroid titration on FENO did not result in higher steroid doses and did improve airway hyperresponsiveness and inflammation.