American journal of respiratory and critical care medicine
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Am. J. Respir. Crit. Care Med. · Mar 2009
Randomized Controlled Trial Multicenter StudyA randomized controlled trial of nurse-led care for symptomatic moderate-severe obstructive sleep apnea.
Obstructive sleep apnea (OSA) is a prevalent disease. Often limited clinical resources result in long patient waiting lists. Simpler validated methods of care are needed. ⋯ A simplified nurse-led model of care has demonstrated noninferior results to physician-directed care in the management of symptomatic moderate-severe OSA, while being less costly. Clinical trial registered with http://www.anzctr.org.au (ACTRN012605000064606).
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Am. J. Respir. Crit. Care Med. · Mar 2009
Multicenter StudyFibrinogen genes modify the fibrinogen response to ambient particulate matter.
Ambient particulate matter has been associated with systemic inflammation indicated by blood markers such as fibrinogen, implicated in promoting atherothrombosis. ⋯ The data suggest that susceptibility to ambient particulate matter may be partly genetically determined by polymorphisms that alter early physiological responses such as transcription of fibrinogen. Subjects with variants of these frequent SNPs may have increased risks not only due to constitutionally higher fibrinogen concentrations, but also due to an augmented response to environmental inflammatory stimuli such as ambient particulate matter.
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Am. J. Respir. Crit. Care Med. · Mar 2009
Multicenter StudyCD14 and toll-like receptor gene polymorphisms, country living, and asthma in adults.
It has been shown that country living protects against asthma, which may be explained by microbial exposures. ⋯ TLR2 and CD14 SNPs were associated with asthma and atopic asthma respectively. In addition, CD14, TLR2, TLR4, and TLR9 SNPs modified associations between country living and asthma.
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Am. J. Respir. Crit. Care Med. · Mar 2009
Multicenter StudyFragile histidine triad gene inactivation in lung cancer: the European Early Lung Cancer project.
Fragile histidine triad (FHIT) is a tumor suppressor gene involved in the pathogenesis of lung cancer. ⋯ Our results indicate that different molecular mechanisms interplay to inactivate FHIT expression and support the proposition that FHIT methylation in normal lung tissue could represent a prognostic marker for progressive disease.