American journal of respiratory and critical care medicine
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Am. J. Respir. Crit. Care Med. · Dec 2011
The response of children with asthma to ambient particulate is modified by tobacco smoke exposure.
Ambient particulate matter concentrations have been positively associated with urinary leukotriene E(4) (LTE(4)) levels and albuterol usage in children with asthma but interactions with environmental tobacco smoke (ETS) exposure have not been demonstrated despite obvious exposure to both pollutants in an urban setting. ⋯ This study suggests that ETS modifies the acute effects of low-level ambient PM(2.5) exposure on childhood asthma. This negative interaction, the smaller effect of particulate matter exposure in children exposed to higher ETS, may be related to a nonlinear dose-response relationship between asthma mediators and particulate exposures.
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Am. J. Respir. Crit. Care Med. · Dec 2011
Letter Biography Historical ArticleAretaeus of Cappadocia and the first clinical description of asthma.
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Am. J. Respir. Crit. Care Med. · Dec 2011
Editorial CommentVitamin D and asthma: another dimension.