American journal of respiratory and critical care medicine
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Am. J. Respir. Crit. Care Med. · Dec 2011
Multicenter StudyHigh prevalence of multidrug-resistant nonfermenters in hospital-acquired pneumonia in Asia.
Hospital-acquired pneumonia (HAP) and ventilator-associated pneumonia (VAP) remain important causes of morbidity and mortality. Increasing antimicrobial resistance has aroused the concern of the failure of antibiotic treatment. ⋯ Acinetobacter spp., P. aeruginosa, S. aureus, and K. pneumoniae are the most frequent isolates from adults with HAP or VAP in Asian countries. These isolates are highly resistant to major antimicrobial agents, which could limit the therapeutic options in the clinical practice. Discordant initial empirical antimicrobial therapy significantly increases the likelihood of pneumonia-related mortality.
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Am. J. Respir. Crit. Care Med. · Dec 2011
Randomized Controlled Trial Multicenter StudyImpact of race on asthma treatment failures in the asthma clinical research network.
Recent studies suggest that people with asthma of different racial backgrounds may respond differently to various therapies. ⋯ Despite having fewer asthma symptoms and less rescue β-agonist use, African-Americans with asthma have more treatment failures compared with whites, especially when taking long-acting β-agonists.