American journal of respiratory and critical care medicine
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Am. J. Respir. Crit. Care Med. · Sep 2012
Randomized Controlled Trial Multicenter StudyEffect of vitamin D and inhaled corticosteroid treatment on lung function in children.
Low vitamin D levels are associated with asthma and decreased airway responsiveness. Treatment with inhaled corticosteroids improves airway responsiveness and asthma control. ⋯ In children with asthma treated with inhaled corticosteroids, vitamin D deficiency is associated with poorer lung function than in children with vitamin D insufficiency or sufficiency.
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Am. J. Respir. Crit. Care Med. · Sep 2012
Comparative StudyDoes bronchial hyperresponsiveness in childhood predict active asthma in adolescence?
Bronchial hyperresponsiveness (BHR) is an important, but not specific, asthma characteristic. ⋯ BHR at 10 years was a significant but modest predictor of active asthma 6 years later, with methacholine challenge being superior to exercise test.
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Am. J. Respir. Crit. Care Med. · Sep 2012
Comparative StudyLung-enriched organisms and aberrant bacterial and fungal respiratory microbiota after lung transplant.
Long-term survival after lung transplantation is limited by infectious complications and by bronchiolitis obliterans syndrome (BOS), a form of chronic rejection linked in part to microbial triggers. ⋯ Respiratory tract microbial communities in lung transplant recipients differ in structure and composition from healthy subjects. Outlier analysis can identify specific bacteria replicating in lung. These findings provide novel approaches to address the relationship between microbial communities and transplant outcome and aid in assessing lung infections.
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Am. J. Respir. Crit. Care Med. · Sep 2012
Comparative StudySpatial clusters of nontuberculous mycobacterial lung disease in the United States.
Prevalence of pulmonary nontuberculous mycobacterial (PNTM) disease varies by geographic region, yet the factors driving these differences remain largely unknown. ⋯ Specific environmental factors related to soil and water exposure appear to increase the risk of PNTM infection. Still, given that environmental sources of NTM are ubiquitous and PNTM disease is rare, both host susceptibility and environmental factors must be considered in explaining disease development.