American journal of respiratory and critical care medicine
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Am. J. Respir. Crit. Care Med. · Nov 2013
Increased Risk of Pneumonia and Bronchiolitis after Bacterial Colonization of the Airways as Neonates.
The frequency of pneumonia and bronchiolitis exhibits considerable variation in otherwise healthy children, and suspected risk factors explain only a minor proportion of the variation. We hypothesized that alterations in the airway microbiome in early life may be associated with susceptibility to pneumonia and bronchiolitis in young children. ⋯ Neonatal airway colonization with S. pneumoniae, H. influenzae, or M. catarrhalis is associated with increased risk of pneumonia and bronchiolitis in early life independently of asthma. This suggests a role of pathogenic bacterial colonization of the airways in neonates for subsequent susceptibly to pneumonia and bronchiolitis.
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Am. J. Respir. Crit. Care Med. · Nov 2013
Editorial CommentShould all patients with asthma receive statins?