American journal of respiratory and critical care medicine
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Am. J. Respir. Crit. Care Med. · Nov 2013
Socioeconomic Status and Childhood Asthma in Urban Minority Youths: The GALA II & SAGE II Studies.
The burden of asthma is highest among socioeconomically disadvantaged populations; however, its impact is differentially distributed among racial and ethnic groups. ⋯ Socioeconomic status plays an important role in predicting asthma, but has different effects depending on race and ethnicity. Further steps are necessary to better understand the risk factors through which socioeconomic status could operate in these populations to prevent asthma.
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Am. J. Respir. Crit. Care Med. · Nov 2013
Clinical TrialDiagnosis and Subtyping of de novo and Relapsed Mediastinal Lymphomas by Endobronchial Ultrasound Needle Aspiration.
The current management of lymphoma requires accurate diagnosis and subtyping of de novo lymphoma and of relapsed or refractory lymphoma in known cases. The role of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) in the clinical management of lymphomas is unclear. ⋯ Multimodality evaluation of EBUS-TBNA can be successful in the diagnosis of de novo mediastinal lymphomas and is ideally suited in distinguishing lymphoma relapse from alternative pathologies; it is least sensitive in subtyping Hodgkin lymphoma.
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Am. J. Respir. Crit. Care Med. · Nov 2013
Clinical TrialThe Effects of Airway Microbiome on Corticosteroid Responsiveness in Asthma.
The role of airway microbiome in corticosteroid response in asthma is unknown. ⋯ A subset of subjects with CR asthma demonstrates airway expansion of specific gram-negative bacteria, which trigger TAK1/MAPK activation and induce corticosteroid resistance. TAK1 inhibition restored cellular sensitivity to corticosteroids.