American journal of respiratory and critical care medicine
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Am. J. Respir. Crit. Care Med. · Jun 2013
Randomized Controlled Trial Multicenter Study Comparative StudyWean earlier and automatically with new technology (the WEAN study). A multicenter, pilot randomized controlled trial.
Automated weaning has not been compared with a paper-based weaning protocol in North America. ⋯ Compared with a standardized protocol, automated weaning was associated with promising outcomes that warrant further investigation. Minor protocol modifications may increase compliance, facilitate recruitment, and enhance feasibility. Clinical trial registered with www.controlled-trials.com (ISRCTN43760151).
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Am. J. Respir. Crit. Care Med. · Jun 2013
Multicenter StudyDisrupted prenatal maternal cortisol, maternal obesity, and childhood wheeze. Insights into prenatal programming.
Exploring prenatal factors influencing childhood wheeze may inform programming mechanisms. ⋯ Maternal prenatal cortisol disruption and obesity were independently associated with children's wheeze. Obese women with adverse cortisol profiles were most likely to have children with repeated wheeze.