American journal of respiratory and critical care medicine
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Am. J. Respir. Crit. Care Med. · Mar 2014
Comparative Study Clinical TrialLung Clearance Index is a Repeatable and Sensitive Indicator of Radiological Changes in Bronchiectasis.
In bronchiectasis there is a need for improved markers of lung function to determine disease severity and response to therapy. ⋯ The lung clearance index is repeatable and a more sensitive measure than FEV1 in the detection of abnormalities demonstrated on CT scan. The lung clearance index has the potential to be a useful clinical and research tool in patients with bronchiectasis.
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Am. J. Respir. Crit. Care Med. · Mar 2014
Patent foramen ovale is not associated with hypoxemia in severe COPD and does not impair exercise performance.
Patent foramen ovale (PFO) may be disadvantageous in chronic obstructive pulmonary disease (COPD). It is unknown whether right-to-left shunting through PFO increases during exercise impairing exercise performance. ⋯ Hypoxemic patients with COPD do not have a higher prevalence of PFO. Patients with COPD with PFO do not perform less well either on a 6-minute walk or submaximal exercise testing despite increased right-to-left shunting during exercise.
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Am. J. Respir. Crit. Care Med. · Mar 2014
Multicenter Study Clinical TrialGenetic Variation in Prostaglandin E2 Pathway is Associated with Primary Graft Dysfunction.
Biologic pathways with significant genetic conservation across human populations have been implicated in the pathogenesis of primary graft dysfunction (PGD). The evaluation of the role of recipient genetic variation in PGD has thus far been limited to single, candidate gene analyses. ⋯ Further research aimed at replication and additional functional insight into the role played by genetic variation in prostaglandin E2 synthetic and signaling pathways in PGD is warranted.