American journal of respiratory and critical care medicine
-
Am. J. Respir. Crit. Care Med. · Mar 2014
Randomized Controlled Trial Multicenter StudyThe Beta Agonist Lung Injury Trial (BALTI) Prevention: A Randomized Controlled Trial.
Experimental studies suggest that pretreatment with β-agonists might prevent acute lung injury (ALI). ⋯ Perioperative treatment with inhaled salmeterol was well tolerated but did not prevent ALI. Clinical trial registered with International Standard Randomized Controlled Trial Register (ISRCTN47481946) and European Union database of randomized Controlled Trials (EudraCT 2007-004096-19).
-
Am. J. Respir. Crit. Care Med. · Mar 2014
Multicenter StudyThe Bronchiectasis Severity Index: An International Derivation and Validation Study.
There are no risk stratification tools for morbidity and mortality in bronchiectasis. Identifying patients at risk of exacerbations, hospital admissions, and mortality is vital for future research. ⋯ The BSI is a useful clinical predictive tool that identifies patients at risk of future mortality, hospitalization, and exacerbations across healthcare systems.
-
Am. J. Respir. Crit. Care Med. · Mar 2014
Multicenter Study Clinical TrialGenetic Variation in Prostaglandin E2 Pathway is Associated with Primary Graft Dysfunction.
Biologic pathways with significant genetic conservation across human populations have been implicated in the pathogenesis of primary graft dysfunction (PGD). The evaluation of the role of recipient genetic variation in PGD has thus far been limited to single, candidate gene analyses. ⋯ Further research aimed at replication and additional functional insight into the role played by genetic variation in prostaglandin E2 synthetic and signaling pathways in PGD is warranted.