American journal of respiratory and critical care medicine
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Am. J. Respir. Crit. Care Med. · Mar 2014
Hospital Case Volume and Outcomes among Patients Hospitalized with Severe Sepsis.
Processes of care are potential determinants of outcomes in patients with severe sepsis. Whether hospitals with more experience caring for patients with severe sepsis also have improved outcomes is unclear. ⋯ Academic hospitals with higher severe sepsis case volume have lower severe sepsis hospital mortality without higher costs.
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Am. J. Respir. Crit. Care Med. · Mar 2014
Intermittent Hypoxia-induced Changes in Tumor-associated Macrophages and Tumor Malignancy in a Mouse Model of Sleep Apnea.
An increased cancer aggressiveness and mortality have been recently reported among patients with obstructive sleep apnea (OSA). Intermittent hypoxia (IH), a hallmark of OSA, enhances melanoma growth and metastasis in mice. ⋯ Our findings support the notion that IH-induced alterations in TAMs participate in the adverse cancer outcomes reported in OSA.
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Am. J. Respir. Crit. Care Med. · Mar 2014
Hyaluronan Contributes to Bronchiolitis Obliterans Syndrome and Stimulates Lung Allograft Rejection through Activation of Innate Immunity.
Although innate immunity is increasingly recognized to contribute to lung allograft rejection, the significance of endogenous innate ligands, such as hyaluronan (HA) fragments, in clinical or experimental lung transplantation is uncertain. ⋯ These data suggest that accumulation of HA could contribute to BOS by directly activating innate immune signaling pathways that promote allograft rejection and neutrophilia.