American journal of respiratory and critical care medicine
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Am. J. Respir. Crit. Care Med. · Jun 2014
Observational StudyTHE NON-ALLERGIC ASTHMA OF OBESITY: A MATTER OF DISTAL LUNG COMPLIANCE.
The pathogenesis of asthma in obesity is poorly understood, but may be related to breathing at low lung volumes. ⋯ Weight loss decompresses the lung in both obese control subjects and patients with asthma, but the more pronounced effects of weight loss on lung elastance suggest that the distal lung is inherently more collapsible in people with asthma.
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Am. J. Respir. Crit. Care Med. · Jun 2014
Genotype-Phenotype Correlations for Infants and Children with ABCA3 Deficiency.
Recessive mutations in the ATP-binding cassette transporter A3 (ABCA3) cause lethal neonatal respiratory failure and childhood interstitial lung disease. Most ABCA3 mutations are private. ⋯ Genotype-phenotype correlations exist for homozygous or compound heterozygous mutations in ABCA3. Frameshift or nonsense ABCA3 mutations are predictive of neonatal presentation and poor outcome, whereas missense, splice site, and insertion/deletions are less reliably associated with age of presentation and prognosis. Counseling and clinical decision making should acknowledge these correlations.