American journal of respiratory and critical care medicine
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Am. J. Respir. Crit. Care Med. · May 2015
Historical ArticleHistory of Mechanical Ventilation: From Vesalius to Ventilator-Induced Lung Injury.
Mechanical ventilation is a life-saving therapy that catalyzed the development of modern intensive care units. The origins of modern mechanical ventilation can be traced back about five centuries to the seminal work of Andreas Vesalius. ⋯ One of the great advances in ventilatory support over the past few decades has been the development of lung-protective ventilatory strategies, based on our understanding of the iatrogenic consequences of mechanical ventilation such as ventilator-induced lung injury. These strategies have markedly improved clinical outcomes in patients with respiratory failure.
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Am. J. Respir. Crit. Care Med. · May 2015
Global Epidemiology of Pediatric Severe Sepsis: the Sepsis PRevalence, OUtcomes, and Therapies Study.
Limited data exist about the international burden of severe sepsis in critically ill children. ⋯ Pediatric severe sepsis remains a burdensome public health problem, with prevalence, morbidity, and mortality rates similar to those reported in critically ill adult populations. International clinical trials targeting children with severe sepsis are warranted.