American journal of respiratory and critical care medicine
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Am. J. Respir. Crit. Care Med. · May 2015
Randomized Controlled Trial Clinical TrialEthanol Lock and Risk of Hemodialysis Catheter Infection in Critically Ill Patients: A Randomized Controlled Trial.
Ethanol rapidly eradicated experimental biofilm. Clinical studies of ethanol lock to prevent catheter-related infections (CRIs) suggest preventive efficacy. No such studies have been done in intensive care units (ICU). ⋯ A 2-minute ethanol lock does not decrease the frequency of infection of DCs in ICU patients. Clinical trial registered with www.clinicaltrials.gov (NCT 00875069).
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Am. J. Respir. Crit. Care Med. · May 2015
Multicenter StudyThe Timing of Discharge from ICU and Subsequent Mortality: A Prospective Multi-center Study.
Previous studies suggested an association between after-hours intensive care unit (ICU) discharge and increased hospital mortality. Their retrospective design and lack of correction for patient factors present at the time of discharge make this association problematic. ⋯ In this large, prospective, multicenter, binational observational study, we found that patient status at ICU discharge, particularly the presence of LOMT orders, was the chief predictor of hospital survival. In contrast to previous studies, the timing of discharge did not have an independent association with mortality.
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Am. J. Respir. Crit. Care Med. · May 2015
Clinical TrialA Dose Ranging Trial to Optimize the Dose of Rifampin in the Treatment of Tuberculosis.
Rifampin at a dose of 10 mg/kg was introduced in 1971 based on pharmacokinetic, toxicity, and cost considerations. Available data in mice and humans showed that an increase in dose may shorten the duration of tuberculosis treatment. ⋯ Two weeks of rifampin up to 35 mg/kg was safe and well tolerated. There was a nonlinear increase in exposure to rifampin without an apparent ceiling effect and a greater estimated fall in bacterial load in the higher dosing groups. Clinical trial registered with www.clinicaltrials.gov (NCT 01392911).