American journal of respiratory and critical care medicine
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Am. J. Respir. Crit. Care Med. · Jul 2015
The Relationship of Mucus Concentration (Hydration) to Mucus Osmotic Pressure and Transport in Chronic Bronchitis.
Chronic bronchitis (CB) is characterized by persistent cough and sputum production. Studies were performed to test whether mucus hyperconcentration and increased partial osmotic pressure, in part caused by abnormal purine nucleotide regulation of ion transport, contribute to the pathogenesis of CB. ⋯ Abnormal regulation of airway surface hydration may slow MCC in CB and contribute to disease pathogenesis.
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Am. J. Respir. Crit. Care Med. · Jul 2015
Longitudinal Forced Vital Capacity Monitoring as a Prognostic Adjunct after Lung Transplantation.
After lung transplantation, spirometric values are routinely followed to assess graft function. FEV1 is used to characterize chronic allograft dysfunction, whereas the course of FVC change has been less acknowledged and rarely used. ⋯ FVC decline from its post-transplant baseline provides valuable prognostic information. Concurrent FEV1 and FVC decline identifies patients with fulminant, rapid deterioration and is the strongest clinical predictor of poor survival. Subsequent FVC decline in patients with an initial isolated FEV1 decline identifies disease progression and portends poor prognosis.