American journal of respiratory and critical care medicine
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Am. J. Respir. Crit. Care Med. · Aug 2015
Timing and Duration of Traffic-Related Air Pollution Exposure and the Risk for Childhood Wheeze and Asthma.
The timing and duration of traffic-related air pollution (TRAP) exposure may be important for childhood wheezing and asthma development. ⋯ Early-life exposure to TRAP is associated with increased risk for persistent wheezing, but only long-term exposure to high levels of TRAP throughout childhood was associated with asthma development.
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Am. J. Respir. Crit. Care Med. · Aug 2015
The Host Response to the Lung Microbiome in Chronic Obstructive Pulmonary Disease.
The relatively sparse but diverse microbiome in human lungs may become less diverse in chronic obstructive pulmonary disease (COPD). This article examines the relationship of this microbiome to emphysematous tissue destruction, number of terminal bronchioles, infiltrating inflammatory cells, and host gene expression. ⋯ These results support the hypothesis that there is a host immune response to microorganisms within the lung microbiome that appears to contribute to the pathogenesis of COPD.