American journal of respiratory and critical care medicine
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Am. J. Respir. Crit. Care Med. · Oct 2016
Multicenter StudyAbnormal Glucose Tolerance in Infants and Young Children with Cystic Fibrosis.
In cystic fibrosis, abnormal glucose tolerance is associated with decreased lung function and worsened outcomes. Translational evidence indicates that abnormal glucose tolerance may begin in early life. ⋯ Abnormal glucose tolerance is notably prevalent among young children with cystic fibrosis. Children with cystic fibrosis lack the normal increase in insulin secretion that occurs in early childhood despite increased glucose. These findings demonstrate that glycemic abnormalities begin very early in cystic fibrosis, possibly because of insufficient insulin secretion.