American journal of respiratory and critical care medicine
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Am. J. Respir. Crit. Care Med. · Nov 2016
Randomized Controlled Trial Multicenter StudyContinuous Positive Airway Pressure Improves Quality of Life in Women with OSA. A Randomized-controlled Trial.
Continuous positive airway pressure (CPAP) is the treatment of choice in patients with symptomatic obstructive sleep apnea (OSA). CPAP treatment improves quality of life (QoL) in men with OSA, but its role in women has not yet been assessed. ⋯ In women with moderate or severe OSA, 3 months of CPAP therapy improved QoL, mood state, anxiety and depressive symptoms, and daytime sleepiness compared with conservative treatment. Clinical trial registered with www.clinicaltrials.gov (NCT02047071).
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Am. J. Respir. Crit. Care Med. · Nov 2016
Multicenter StudyUltrafine and Fine Particles and Hospital Admissions in Central Europe, Results from the UFIREG Study.
Evidence of short-term effects of ultrafine particles (UFP) on health is still inconsistent and few multicenter studies have been conducted so far especially in Europe. ⋯ Our findings indicated delayed and prolonged effects of UFP exposure on respiratory hospital admissions in Central and Eastern Europe. Cardiovascular and respiratory hospital admissions increased in association with an increase in PM2.5. Further multicenter studies are needed using harmonized UFP measurements to draw definite conclusions on health effects of UFP.
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Am. J. Respir. Crit. Care Med. · Nov 2016
Randomized Controlled Trial Multicenter StudyEndobronchial Valve Therapy in Patients with Homogeneous Emphysema: Results from the IMPACT Study.
Endobronchial valves (EBVs) have been successfully used in patients with severe heterogeneous emphysema to improve lung physiology. Limited available data suggest that EBVs are also effective in homogeneous emphysema. ⋯ EBV in patients with homogeneous emphysema without collateral ventilation results in clinically meaningful benefits of improved lung function, exercise tolerance, and quality of life.
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Am. J. Respir. Crit. Care Med. · Nov 2016
Randomized Controlled Trial Multicenter Study Pragmatic Clinical TrialImproving Appropriate Neurological Prognostication After Cardiac Arrest: A Stepped Wedge Cluster RCT.
Predictions about neurologic prognosis that are based on early clinical findings after out-of-hospital cardiac arrest (OHCA) are often inaccurate and may lead to premature decisions to withdraw life-sustaining treatments (LST) in patients who might otherwise survive with good neurologic outcomes. ⋯ A multicenter quality intervention improved rates of appropriate neurologic prognostication after OHCA but did not increase survival with good neurologic outcome. Clinical trial registered with www.clinicaltrials.gov (NCT 01472458).