American journal of respiratory and critical care medicine
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Am. J. Respir. Crit. Care Med. · Dec 2016
Intra-tumoral Immune Cell Densities are Associated with Lung Adenocarcinoma Gene Alterations.
Tumor-infiltrating immune cells affect lung cancer outcome. However, the factors that influence the composition and function of the tumor immune environment remain poorly defined and need investigation, particularly in the era of immunotherapy. ⋯ Intratumoral immune cell densities (mDCs, CD8+ T cells, neutrophils, macrophages) were significantly associated with molecular alterations in adenocarcinoma underlying the interactions between cancer cells and their microenvironment.