American journal of respiratory and critical care medicine
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Am. J. Respir. Crit. Care Med. · May 2016
Randomized Controlled Trial Multicenter StudyA Randomized Trial of an Intensive Physical Therapy Program for Acute Respiratory Failure Patients.
Early physical therapy (PT) interventions may benefit patients with acute respiratory failure by preventing or attenuating neuromuscular weakness. However, the optimal dosage of these interventions is currently unknown. ⋯ An intensive PT program did not improve long-term physical functional performance compared with a standard-of-care program. Clinical trial registered with www.clinicaltrials.gov (NCT01058421).
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Am. J. Respir. Crit. Care Med. · May 2016
Desmoplakin (DSP) Variants are Associated with Idiopathic Pulmonary Fibrosis.
Sequence variation, methylation differences, and transcriptional changes in desmoplakin (DSP) have been observed in patients with idiopathic pulmonary fibrosis (IPF). ⋯ Sequence variants in DSP are associated with IPF, and rs2076295 genotype is associated with differential expression of DSP in the lung. DSP expression is increased in IPF lung and concentrated in the airway epithelia, suggesting a potential role for DSP in the pathogenesis of IPF.
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Am. J. Respir. Crit. Care Med. · May 2016
Observational StudyLong-Term Ozone Exposure and Mortality in a Large Prospective Study.
Tropospheric ozone (O3) is potentially associated with cardiovascular disease risk and premature death. Results from long-term epidemiological studies on O3 are scarce and inconclusive. ⋯ Findings derived from this large-scale prospective study suggest that long-term ambient O3 contributes to risk of respiratory and circulatory mortality. Substantial health and environmental benefits may be achieved by implementing further measures aimed at controlling O3 concentrations.
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Am. J. Respir. Crit. Care Med. · May 2016
Observational StudyLong-Term Ozone Exposure Increases the Risk of Developing the Acute Respiratory Distress Syndrome.
The contribution of air pollution to the risk of acute respiratory distress syndrome (ARDS) is unknown. ⋯ Long-term ozone exposure is associated with development of ARDS in at-risk critically ill patients, particularly in trauma patients and current smokers. Ozone exposure may represent a previously unrecognized environmental risk factor for ARDS.