American journal of respiratory and critical care medicine
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Am. J. Respir. Crit. Care Med. · Jan 2017
Gene Expression Profiling in Blood Provides Reproducible Molecular Insights into Asthma Control.
Maintaining optimal symptom control remains the primary objective of asthma treatment. Better understanding of the biologic underpinnings of asthma control may lead to the development of improved clinical and pharmaceutical approaches. ⋯ Together, these results demonstrate the existence of specific, reproducible transcriptomic components in blood that vary with degree of asthma control and implicate a novel biologic target (TREM-1).
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Am. J. Respir. Crit. Care Med. · Jan 2017
Multicenter Study Observational StudyPeripheral Artery Disease and its Clinical Relevance in Patients with COPD in the COSYCONET Study.
Knowledge about the prevalence of objectively assessed peripheral artery disease (PAD) and its clinical relevance in patients with chronic obstructive pulmonary disease (COPD) is scarce. ⋯ In a large cohort of patients with COPD, 8.8% were diagnosed with PAD, which is higher than the prevalence in control subjects without COPD. PAD was associated with a clinically relevant reduction in functional capacity and health status.
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Am. J. Respir. Crit. Care Med. · Jan 2017
Maternal Folate Intake During Pregnancy and Childhood Asthma in a Population Based Cohort.
A potential adverse effect of high folate intake during pregnancy on children's asthma development remains controversial. ⋯ In this large prospective population-based cohort with essentially complete follow-up, pregnant women taking supplemental folic acid at or above the recommended dose, combined with a diet rich in folate, reach a total folate intake level associated with a slightly increased risk of asthma in children.
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Am. J. Respir. Crit. Care Med. · Jan 2017
Resonance as the Mechanism of Daytime Periodic Breathing in Patients with Heart Failure.
In patients with chronic heart failure, daytime oscillatory breathing at rest is associated with a high risk of mortality. Experimental evidence, including exaggerated ventilatory responses to CO2 and prolonged circulation time, implicates the ventilatory control system and suggests feedback instability (loop gain > 1) is responsible. However, daytime oscillatory patterns often appear remarkably irregular versus classic instability (Cheyne-Stokes respiration), suggesting our mechanistic understanding is limited. ⋯ Our study elucidates the mechanism underlying daytime ventilatory oscillations in heart failure and provides a means to measure and interpret these oscillations to reveal the underlying chemoreflex hypersensitivity and reduced stability that foretells mortality in this population.