American journal of respiratory and critical care medicine
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Am. J. Respir. Crit. Care Med. · Oct 2017
Multicenter StudyJoblessness and Lost Earnings After ARDS in a 1-Year National Multicenter Study.
Following acute respiratory distress syndrome (ARDS), joblessness is common but poorly understood. ⋯ At 12 months after ARDS, nearly one-half of previously employed survivors were jobless. Post-ARDS joblessness is associated with readily identifiable patient and hospital variables and accompanied by substantial lost earnings and a shift toward government-funded healthcare coverage.
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Am. J. Respir. Crit. Care Med. · Oct 2017
Multicenter StudyEffects of Omalizumab on Rhinovirus Infections, Illnesses and Exacerbations of Asthma.
Allergic inflammation has been linked to increased susceptibility to viral illnesses, but it is unclear whether this association is causal. ⋯ In children with allergic asthma, treatment with omalizumab decreased the duration of RV infections, viral shedding, and the risk of RV illnesses. These findings provide direct evidence that blocking IgE decreases susceptibility to RV infections and illness. Clinical trial registered with www.clinicaltrials.gov (NCT01430403).
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Am. J. Respir. Crit. Care Med. · Oct 2017
Multicenter StudyAssociations of Nasopharyngeal Metabolome and Microbiome with Severity Among Infants with Bronchiolitis: A Multi-omic Analysis.
Bronchiolitis is the most common lower respiratory infection in infants; however, it remains unclear which infants with bronchiolitis will develop severe illness. In addition, although emerging evidence indicates associations of the upper-airway microbiome with bronchiolitis severity, little is known about the mechanisms linking airway microbes and host response to disease severity. ⋯ Although further validation is needed, our multiomic analyses demonstrate the potential of metabolomics to predict bronchiolitis severity and better understand microbe-host interaction.