American journal of respiratory and critical care medicine
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Am. J. Respir. Crit. Care Med. · Jul 2017
Randomized Controlled TrialPreventing Severe Asthma Exacerbations in Children: A Randomised Trial of Mite Impermeable Bedcovers.
Allergen exposure in sensitized individuals with asthma interacts with viruses to increase the risk of asthma exacerbation. ⋯ Mite-impermeable encasings are effective in reducing the number of mite-sensitized children with asthma attending the hospital with asthma exacerbations but not the number requiring oral prednisolone. This simple measure may reduce the health care burden of asthma exacerbations in children. Clinical trial registered with www.isrctn.com (ISRCTN 69543196).
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Am. J. Respir. Crit. Care Med. · Jul 2017
Microbes Associate with Host Innate Immune Response in Idiopathic Pulmonary Fibrosis.
Differences in the lung microbial community influence idiopathic pulmonary fibrosis (IPF) progression. Whether the lung microbiome influences IPF host defense remains unknown. ⋯ These findings suggest that host-microbiome interactions influence PFS and fibroblast responsiveness.
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Am. J. Respir. Crit. Care Med. · Jul 2017
Reduced Frizzled Receptor 4 Expression Prevents WNT/β-catenin-driven Alveolar Lung Repair in COPD.
Chronic obstructive pulmonary disease (COPD), in particular emphysema, is characterized by loss of parenchymal alveolar tissue and impaired tissue repair. Wingless and INT-1 (WNT)/β-catenin signaling is reduced in COPD; however, the mechanisms thereof, specifically the role of the frizzled (FZD) family of WNT receptors, remain unexplored. ⋯ Reduced FZD4 expression in COPD contributes to impaired alveolar repair capacity.