American journal of respiratory and critical care medicine
-
Am. J. Respir. Crit. Care Med. · Sep 2017
Letter Randomized Controlled TrialRandomized Double-blind Controlled Trial of Roflumilast at Acute Exacerbations of COPD.
-
Am. J. Respir. Crit. Care Med. · Sep 2017
Autophagy Primes Neutrophils for Neutrophil Extracellular Trap Formation During Sepsis.
Neutrophils are key effectors in the host's immune response to sepsis. Excessive stimulation or dysregulated neutrophil functions are believed to be responsible for sepsis pathogenesis. However, the mechanisms regulating functional plasticity of neutrophils during sepsis have not been fully determined. ⋯ These results indicate that neutrophil autophagy primes neutrophils for increased NET formation, which is important for proper neutrophil effector functions during sepsis. Our study provides important insights into the role of autophagy in neutrophils during sepsis.
-
Am. J. Respir. Crit. Care Med. · Sep 2017
Volume Controlled Ventilation Does Not Prevent Injurious Inflation During Spontaneous Effort.
Spontaneous breathing during mechanical ventilation increases transpulmonary pressure and Vt, and worsens lung injury. Intuitively, controlling Vt and transpulmonary pressure might limit injury caused by added spontaneous effort. ⋯ Limitation of Vt and Pl(es) by volume-controlled ventilation could not eliminate harm caused by spontaneous breathing unless the level of spontaneous effort was lowered and local dependent lung stress was reduced.