American journal of respiratory and critical care medicine
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Am. J. Respir. Crit. Care Med. · Feb 2018
Multicenter Study Controlled Clinical TrialImprovement in Right Ventricular Strain with Ambrisentan and Tadalafil Upfront Therapy in Scleroderma Pulmonary Arterial Hypertension.
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Am. J. Respir. Crit. Care Med. · Feb 2018
Multicenter Study Observational StudyCardiovascular Disease Does Not Predict Exacerbation Rate or Mortality in COPD.
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Am. J. Respir. Crit. Care Med. · Feb 2018
Comparative StudyCOPD Alters Immune Cell Composition and Immune Checkpoint Inhibitor Efficacy in NSCLC.
Chronic obstructive pulmonary disease (COPD) and non-small cell lung cancer (NSCLC) are interrelated diseases with substantial mortality, and the pathogenesis of both involves aberrant immune functioning. ⋯ In patients with COPD, Th1 cell populations were expanded in both lung and tumor microenvironments, and the presence of COPD was associated with longer progression-free intervals in patients treated with ICIs. This has implications for understanding the immune mediators of COPD and developing novel therapies for NSCLC.
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Am. J. Respir. Crit. Care Med. · Feb 2018
Randomized Controlled Trial Comparative StudyBronchial Provocation Testing Can Be Improved by Using Dry Powder Adenosine Instead of Nebulized AMP.
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Am. J. Respir. Crit. Care Med. · Feb 2018
Effect of Early Life Geohelminth Infections on the Development of Wheezing at 5 Years of Age.
Exposures to geohelminths during gestation or early childhood may reduce risk of wheezing illness/asthma and atopy during childhood in tropical regions. ⋯ Although maternal exposures to geohelminths may increase childhood wheeze, childhood geohelminths during the first 3 years may provide protection through a nonallergic mechanism. Registered as an observational study (ISRCTN41239086).