American journal of respiratory and critical care medicine
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Am. J. Respir. Crit. Care Med. · May 2018
Randomized Controlled Trial Multicenter StudyIntensified Therapy with Inhaled Corticosteroids and LABA at the Onset of URTI to Prevent COPD Exacerbations- A Multicentre, Randomised, Double-blind, Placebo-controlled Trial.
The efficacy of intensified combination therapy with inhaled corticosteroids (ICS) and long-acting β2-agonists (LABA) at the onset of upper respiratory tract infection (URTI) symptoms in chronic obstructive pulmonary disease (COPD) is unknown. ⋯ Intensified combination therapy with ICS/LABA for 10 days at URTI onset did not decrease the incidence of any COPD exacerbation but prevented severe exacerbation. Patients with more severe disease had a significant risk reduction for any exacerbation. Clinical trial registered with www.isrctn.com (ISRCTN45572998).
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Am. J. Respir. Crit. Care Med. · May 2018
Randomized Controlled Trial Comparative StudyLow-Dose Nocturnal Dexmedetomidine Prevents ICU Delirium. A Randomized, Placebo-controlled Trial.
Dexmedetomidine is associated with less delirium than benzodiazepines and better sleep architecture than either benzodiazepines or propofol; its effect on delirium and sleep when administered at night to patients requiring sedation remains unclear. ⋯ Nocturnal administration of low-dose dexmedetomidine in critically ill adults reduces the incidence of delirium during the ICU stay; patient-reported sleep quality appears unchanged. Clinical trial registered with www.clinicaltrials.gov (NCT01791296).