Croatian medical journal
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Croatian medical journal · Jun 2015
Structural variation on the human Y chromosome from population-scale resequencing.
To investigate the information about Y-structural variants (SVs) in the general population that could be obtained by low-coverage whole-genome sequencing. ⋯ We confirmed that Y-SVs were readily detected from low-coverage sequence data and were abundant on the chromosome. We also reported both common and rare Y-SVs that are novel.
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Croatian medical journal · Jun 2015
ReviewPostmortem diagnosis of diabetes mellitus and its complications.
Diabetes mellitus has become a major cause of death worldwide and diabetic ketoacidosis is the most common cause of death in children and adolescents with type 1 diabetes. Acute complications of diabetes mellitus as causes of death may be difficult to diagnose due to missing characteristic macroscopic and microscopic findings. ⋯ In this article, we performed a review of the literature pertaining to the diagnostic performance of classical and novel biochemical parameters that may be used in the forensic casework to identify disorders in glucose metabolism. We also present a review focusing on the usefulness of traditional and alternative specimens that can be sampled and subsequently analyzed to diagnose acute complications of diabetes mellitus as causes of death.
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Croatian medical journal · Jun 2015
Randomized Controlled TrialIntraoperative volume restriction in esophageal cancer surgery: an exploratory randomized clinical trial.
To investigate whether the fluid volume administered during esophageal cancer surgery affects pulmonary gas exchange and tissue perfusion. ⋯ Restriction of intraoperative applied volume does not significantly affect pulmonary exchange function or tissue perfusion in patients undergoing surgical treatment for esophageal cancer.
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Croatian medical journal · Jun 2015
Analysis of mixtures using next generation sequencing of mitochondrial DNA hypervariable regions.
To apply massively parallel and clonal sequencing (next generation sequencing or NGS) to the analysis of forensic mixed samples. ⋯ This study demonstrates the power of NGS technologies targeting the mtDNA HVI/HVII regions for analysis of challenging forensic samples, such as mixtures and specimens with limited DNA.