Croatian medical journal
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Croatian medical journal · Feb 2021
ReviewNon-alcoholic fatty liver disease - a procoagulant condition?
Non-alcoholic fatty liver disease (NAFLD) is associated with a number of extrahepatic comorbidities and considerable cardiovascular morbidity and mortality, which is possibly related to coagulation changes associated with metabolic syndrome. Coagulation disorders are common in patients with liver disease of any etiology, and here we review possible alterations in coagulation cascade specific to NAFLD. We discuss derangements in the coagulation cascade and fibrinolysis, endothelial dysfunction, and platelet abnormalities as possible culprits for altered coagulation and explore the significance of these changes for potential treatment targets.
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Croatian medical journal · Feb 2021
Comparison of prognostic scores for alcoholic hepatitis: a retrospective study.
To explore the prognostic value of modified Discriminant Function (mDF), Glasgow Alcoholic Hepatitis Score (GAHS), Model of End Stage Liver Disease (MELD), Age-Bilirubin-International Normalized Ratio-Creatinine score (ABIC), and the Lille Model for the 28- and 90-day mortality in patients with alcoholic hepatitis. ⋯ There is a need for better prognostic indicators for patients with AH.
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Croatian medical journal · Feb 2021
Which factors influence liver stiffness measured by real-time two dimensional shear wave elastography in patients on maintenance hemodialysis?
To evaluate liver stiffness (LS) by real-time two-dimensional shear wave elastography (RT 2D-SWE) and to assess its correlation with the mean arterial pressure (MAP) in patients on maintenance hemodialysis (MHD). The secondary aim was to identify biological and biochemical parameters associated with elevated LS. ⋯ Mean arterial pressure is correlated with increased LS in patients on MHD. Our results emphasize the importance of proper regulation of arterial blood pressure and indicate that LS should always be interpreted in combination with laboratory parameters. Further prospective studies with larger series are needed.
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Croatian medical journal · Feb 2021
Association of the imaging characteristics of desmoplasia on digital breast tomosynthesis and the Ki-67 proliferation index in invasive breast cancer.
To evaluate the imaging characteristics of desmoplasia on digital breast tomosynthesis (DBT) and their association with the Ki-67 index. ⋯ The spiculation analysis could be used as a non-invasive method providing information about malignant lesions. The tumor proliferative activity, and therefore the patient's prognosis, might be predicted before biopsy directly from DBT images.